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  6.  » Are Ashkenazi Jews Less Vulnerable to A Vaccine That Ethnically Discriminates?

Commentary – Aug 14, 2021

I am not medically or scientifically qualified enough to comment on the following report, so I will say nothing about its medical/technical aspects. However, it does seem to suggest that the degree of the Covid vaccine’s impact depends on the ethnicity of those vaccinated.

Significantly, Ashkenazi Jews seem less vulnerable to the vaccines’ side effects than other groups.

We leave readers to draw their own conclusions on what this implies. Ed.

ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity

Science Direct – Biochemistry and Biophysics Report Dec 2020

Highlights

  • ACE2-K26R decreases SARS-CoV-2/ACE2 electrostatic attraction.
  • ACE2-I468V, R219C, K341R, D206G, G211R increase electrostatic attraction.
  • The variants analyzed vary in frequency between different populations.
  • Our findings suggest a link between ACE2 variations and infection risk.

Abstract

The susceptibility of different populations to SARS-CoV-2 infection is not yet understood. Here, we combined ACE2 coding variants’ analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. ACE2-K26R; which is most frequent in Ashkenazi Jewish population decreased the SARS-CoV-2/ACE2 electrostatic attraction. On the contrary, ACE2-I468V, R219C, K341R, D206G, G211R increased the electrostatic attraction; ordered by binding strength from weakest to strongest. The aforementioned variants are most frequent in East Asian, South Asian, African and African American, European, European and South Asian populations, respectively.

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